Andrea Cavalli Selected Research

AP 2238

3/2010	Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
6/2003	3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.

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Andrea Cavalli Research Topics

Disease

30	Alzheimer Disease (Alzheimer's Disease) 03/2022 - 03/2003
23	Neoplasms (Cancer) 06/2022 - 01/2002
10	Pain (Aches) 02/2018 - 03/2010
9	Inflammation (Inflammations) 01/2019 - 03/2010
7	Chronic Renal Insufficiency 01/2012 - 08/2008
6	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2020 - 02/2008
5	Anemia 01/2022 - 08/2008
5	Breast Neoplasms (Breast Cancer) 05/2017 - 05/2002
4	COVID-19 05/2022 - 07/2020
4	Prostatic Neoplasms (Prostate Cancer) 05/2022 - 01/2018
4	Long QT Syndrome 04/2008 - 01/2002
3	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 02/2004
3	Amyloidosis 10/2021 - 11/2020
3	Cognitive Dysfunction 01/2016 - 01/2012
2	Infections 05/2022 - 11/2010
2	Reinfection 04/2022 - 10/2021
2	Schizophrenia (Dementia Praecox) 01/2022 - 11/2018
2	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020 - 03/2019
2	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 09/2020 - 08/2020
2	Feeding and Eating Disorders (Eating Disorder) 09/2020 - 08/2020
2	Neuroinflammatory Diseases 01/2019 - 01/2019
2	Amnesia (Dissociative Amnesia) 01/2013 - 01/2012
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2011 - 10/2005
2	Torsades de Pointes (Torsade de Pointes) 03/2005 - 01/2002
1	Post-Acute COVID-19 Syndrome 05/2022
1	Virus Diseases (Viral Diseases) 04/2022
1	Autoimmune Lymphoproliferative Syndrome 01/2022
1	Cartilage-hair hypoplasia 01/2022
1	Transthyretin-Related Hereditary Amyloidosis 10/2021
1	Lymphadenopathy 10/2021
1	Agammaglobulinemia (Hypogammaglobulinemia) 10/2021
1	Central Nervous System Diseases (CNS Diseases) 08/2021
1	Pituitary Apoplexy 06/2021

Drug/Important Bio-Agent (IBA)

22	Pharmaceutical PreparationsIBA 07/2019 - 01/2002
10	Proteins (Proteins, Gene)FDA Link 05/2022 - 02/2004
9	LigandsIBA 06/2022 - 10/2007
9	EnzymesIBA 01/2021 - 05/2002
9	Biological ProductsIBA 07/2019 - 07/2004
7	Amyloid (Amyloid Fibrils)IBA 10/2021 - 05/2011
5	Memantine (Namenda)FDA Link 01/2019 - 01/2012
5	memoquinIBA 01/2013 - 11/2007
4	Galantamine (Galanthamine)FDA LinkGeneric 01/2019 - 01/2012
4	Aromatase (CYP19)IBA 05/2017 - 05/2002
4	anandamide (arachidonylethanolamide)IBA 02/2015 - 11/2011
4	Amyloid beta-PeptidesIBA 01/2013 - 06/2003
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2005
3	Cholinergic Agents (Cholinergics)IBA 01/2019 - 06/2005
3	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 01/2015 - 10/2011
3	SodiumIBA 01/2011 - 01/2010
3	AcetylcholinesteraseIBA 08/2008 - 06/2003
3	Estrogens (Estrogen)FDA Link 01/2008 - 05/2002
2	Antiviral Agents (Antivirals)IBA 05/2022 - 01/2017
2	Mutant Proteins (Protein, Mutant)IBA 01/2022 - 01/2018
2	Phenylalanine (L-Phenylalanine)FDA Link 01/2022 - 01/2018
2	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 03/2005
2	Prealbumin (Transthyretin)IBA 10/2021 - 11/2020
2	HMGB1 Protein (HMG1)IBA 01/2021 - 01/2019
2	olaparibIBA 12/2020 - 03/2019
2	Antidepressive Agents (Antidepressants)IBA 09/2020 - 08/2020
2	ARN14140IBA 01/2019 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 01/2019 - 09/2010
2	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA 01/2018 - 01/2018
2	CytochromesIBA 05/2017 - 01/2002
2	CarbamatesIBA 01/2017 - 11/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2013 - 02/2013
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 03/2013 - 12/2007
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 03/2013 - 08/2008
2	Scopolamine (Hyoscine)FDA Link 01/2013 - 01/2012
2	Thioctic Acid (Lipoic Acid)IBA 04/2011 - 11/2006
2	HematinicsIBA 09/2010 - 08/2008
2	AP 2238IBA 03/2010 - 06/2003
2	ElectrolytesIBA 01/2010 - 01/2002
2	Aromatase InhibitorsIBA 01/2008 - 05/2002
2	PolyaminesIBA 10/2007 - 03/2003
1	Dopamine Receptors (Dopamine Receptor)IBA 06/2022
1	Monoclonal AntibodiesIBA 05/2022
1	AntibodiesIBA 05/2022
1	InterferonsIBA 05/2022
1	Immunologic Factors (Immunomodulators)IBA 05/2022
1	ChemokinesIBA 05/2022
1	Immunoglobulin IsotypesIBA 04/2022
1	Viral ProteinsIBA 04/2022
1	Immunoglobulin G (IgG)IBA 04/2022
1	nirmatrelvir and ritonavir drug combinationIBA 04/2022
1	Glycogen Synthase Kinase 3 betaIBA 03/2022
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 03/2022
1	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 01/2022
1	Sirolimus (Rapamycin)FDA Link 01/2022
1	Clozapine (Clozaril)FDA LinkGeneric 01/2022
1	SteroidsIBA 10/2021
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 10/2021
1	Intravenous Immunoglobulins (IVIG)FDA Link 10/2021
1	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 10/2021
1	Protein Kinases (Protein Kinase)IBA 08/2021
1	Lysine (L-Lysine)FDA Link 01/2021

Therapy/Procedure

13	Therapeutics 10/2021 - 03/2003
6	Renal Dialysis (Hemodialysis) 07/2020 - 01/2010
2	Peritoneal Dialysis 01/2012 - 03/2010
1	Treatment Delay 10/2021
1	Conservative Treatment 06/2021